The Powerpuff Girls

Blossom, Bubbles and Buttercup could go from adorable to beating down a monster before bedtime. The Powerpuff Girls had a look you could recognize immediately, three leads you naturally picked between, and villains weird enough to keep Townsville permanently in trouble. Against Dexter’s Laboratory, it’s a Cartoon Network fight with serious bragging rights. Against Batman, the contrast gets even better: two superhero cartoons that could hardly look or feel more different. Don’t let the bows and big eyes fool you—this trio can absolutely bust a bracket.