Skeletor (He-Man and the Masters of the Universe)

Skeletor could win 'Greatest Cartoon Villain of All Time' just by laughing. Seriously, that cackle is a mix of 'evil genius' and 'I just stubbed my toe.' Fans get it—while you're trying to admire his evil plans, you're also wondering where he shops for hoodies. And let's not forget every Skeletor scheme ends with him getting booted out like an unruly cat. It’s the perfect blend of nostalgia and face-palm, which keeps us all hilariously hooked and fiercely debating his rank in villain history.