Sam & Dean Winchester (Supernatural)

Imagine pitting Sam & Dean Winchester against any TV duo and not immediately thinking 'Game Over, folks.' These brothers don’t just fight supernatural baddies—they own the 'Greatest Iconic TV Duos of All Time' league with a trunk full of salt and snarky one-liners. Ever tried arguing with a Supernatural fan? It’s like trying to convince a vampire to try a kale salad. Impossible! They’ll parade every epic brotherly moment, every apocalypse stopped. Choosing anyone else feels like betrayal on a cosmic level. Drama much? Absolutely. And we wouldn’t have it any other way.