Jack Byrnes (Meet the Parents)

If Jack Byrnes from 'Meet the Parents' isn't peak De Niro in a comedy, then I don't know what is. Here’s a guy who turns a lie detector test into a dinner party game. Classic! The man's a human polygraph with a knack for making you squirm and laugh in equal measure. Fans literally split into camps over whether his paranoia is hilarious or just plain terrifying. And let’s not even get started on the cat milking story. How does anyone keep a straight face? This role is a comedic gem that keeps on giving in the debates!